Synergistic Effects of HIV in Aminoglycoside Ototoxicity
نویسندگان
چکیده
منابع مشابه
Prevention and modulation of aminoglycoside ototoxicity (Review).
More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, the clinical use of AGs is hampered by nephrotoxicity and ototoxicity, which often develop as a consequence of prolonged courses of therapy, or of administration of increased doses of th...
متن کاملAn energy-dependent step in aminoglycoside ototoxicity: prevention of gentamicin ototoxicity during reduced endolymphatic potential.
Guinea pigs received a bolus of gentamicin (10 mM for 5 min) by perilymphatic perfusion which normally led to an irreversible loss of the cochlear microphonic potential (CM). Various experimental conditions that reduced the endolymphatic potential (EP) were then superimposed on the gentamicin application. Reversible reductions in EP (and, concomitantly, in CM) were induced by asphyxia (3 min), ...
متن کاملMechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. These mechanisms are ...
متن کاملFunctional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity
Aminoglycosides (AG) are commonly prescribed antibiotics with potent bactericidal activities. One main side effect is permanent sensorineural hearing loss, induced by selective inner ear sensory hair cell death. Much work has focused on AG's initiating cell death processes, however, fewer studies exist defining mechanisms of AG uptake by hair cells. The current study investigated two proposed m...
متن کاملOtotoxicity studies with BB-K8, a new semisynthetic aminoglycoside antibiotic.
BB-K 8, a new semisynthetic aminoglycosidic antibiotic, was evaluated for ototoxicity, nephrotoxicity and neuromuscular blocking activity in the cat. As a reference, kanamycin was tested by the same experimental methods. Employing equivalent doses in terms of the free base and 7 days of intraperitoneal treatment, BB-K8 and kanamycin were found to be similarly ototoxic and nephrotoxic. Acutely, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Otolaryngology–Head and Neck Surgery
سال: 2010
ISSN: 0194-5998,1097-6817
DOI: 10.1016/j.otohns.2010.06.934